What are the applications of outer coil stainless steel towers in the pharmaceutical industry
Information summary：The outer coil tower is different from jacket and inner coil equipment in that it has a large heat exchange area, no heat exchange components inside the kettle, smooth inner walls without dead corners, uniform heat transfer, and is easy to clean and sterilize according to GMP. The mainstream material is 316L/304 stainless steel mirror polishing, which is suitable for the full chain process of raw
The outer coil tower is different from jacket and inner coil equipment in that it has a large heat exchange area, no heat exchange components inside the kettle, smooth inner walls without dead corners, uniform heat transfer, and is easy to clean and sterilize according to GMP. The mainstream material is 316L/304 stainless steel mirror polishing, which is suitable for the full chain process of raw materials, traditional Chinese medicine, sterile preparations, and solvent recovery.
1、 Traditional Chinese Medicine and Natural Medicine Section (with large usage)
1. Multi functional outer coil extraction tower (percolation/reflux/warm soaking)
Water decoction and alcohol extraction process
For traditional Chinese medicinal materials such as roots, flowers, leaves, and seeds, steam/thermal oil is evenly heated through the outer coil, and there is no internal coil obstruction inside the tower, ensuring sufficient material rolling; Supports extraction under normal pressure, reduced pressure, and pressure, effectively extracting active ingredients such as saponins, flavonoids, alkaloids, etc.
Separation of Aromatic Oil (Volatile Oil)
Equipped with a condenser and oil-water separator, the outer coil of the tower is properly controlled for slow steaming, collecting medicinal essential oils such as peppermint, hoplin, rose, and chuanxiong, without local high temperature damaging the aroma and efficacy of the essential oils.
Recovery of drug residue solvent
After extraction is completed, negative pressure distillation is carried out inside the tower, and stable heating is provided by the outer coil. Extraction solvents such as ethanol and acetone are recovered, and the cost is reduced by circulation. There is no volatile pollution in the sealed environment.
GMP Cleanliness Advantage
The inner wall of the tower is polished with a mirror finish, without any weld dead corners or internal coil obstruction. It can be directly cleaned by CIP online spray and sterilized by SIP pure steam to prevent the hiding and mold growth of medicinal residues.
2. Vacuum concentration tower (outer coil low-temperature concentration)
Vacuum low-temperature concentration of traditional Chinese medicine extract: The boiling point is lowered by vacuum degree, and the outer tube provides mild heating (40-60 ℃). Thermally sensitive polysaccharides, peptides, and flavonoids will not degrade at high temperatures, ensuring drug efficacy;
Suitable for high viscosity paste: There is no inner coil inside the tower, and the flow of high viscosity paste is unobstructed, making it less prone to wall sticking and coking; Compared with the jacketed tower, the heat transfer efficiency has been improved by more than 25%, and the concentration rate is faster.
2、 Chemical API synthesis and refining
1. Synthesis reaction tower (esterification, acylation, addition, condensation)
The synthesis of raw materials such as antibiotics, vitamins, sartans, and hypoglycemic drugs is achieved with an external coil tube that maintains a high-precision constant temperature of ± 0.5 ℃, preventing local overheating from producing large amounts of impurities and improving the purity and yield of the raw materials.
Quick switching between hot and cold media: reaction heating → insulation → cooling crystallization completed by one set of equipment; For large volume (10m ³ or more) synthesis towers, the outer coil structure is preferred, which does not occupy the internal mixing space and is suitable for strong mixing with large propeller blades.
Acid and alkali corrosion resistance: 316L and 317L materials are used for the outer coil tower when in contact with strong acid/salt media. The outer wall heat exchange medium does not come into contact with the chemical solution, and there is no risk of leakage and contamination of the raw materials.
2. Crystallization purification tower
Cooling and recrystallization of active pharmaceutical ingredients: Low temperature chilled water is introduced into the outer coil tube, and the temperature is slowly and uniformly reduced. The crystal particles are uniform and fine, reducing the impurities in the mother liquor carried by fine crystals;
The tower is smooth and without protrusions, and the material is discharged smoothly after crystallization is completed. There are no dead corners for crystal adhesion, and the cleaning loss is relatively low.
3. Solvent distillation recovery tower
Large scale distillation purification of medicinal solvents such as ethanol, methanol, dichloromethane, and ethyl acetate:
The external coil tube provides stable heating to maintain the temperature of the distillation tower kettle, and the gas-liquid equilibrium is stable. The solvent purity can reach pharmaceutical grade (above 99.5%);
Sealed negative pressure distillation, explosion-proof structure suitable for flammable organic solvents, recycling solvents for reuse, significantly reducing hazardous waste and procurement costs.
3、 Aseptic preparations and biopharmaceutical field
1. Fermentation temperature control tower (vertical tower type of biological fermentation tank)
Fermentation of probiotics, antibiotic hyphae, and vaccine strains:
The outer coil has a large heat exchange area, which quickly takes away the biological heat of fermentation, and maintains a stable cultivation temperature of 30-37 ℃ throughout the process to avoid high-temperature burning of bacterial strains;
There are no internal coils inside the tower, the stirring flow field is unobstructed, the dissolved oxygen is uniform, and the bacterial growth is stable; 316L sanitary grade material supports 121 ℃ online steam sterilization (SIP), meeting sterile GMP A/B workshop standards.
2. Injection water/pure steam matching heat exchange tower
The water for injection (WFI) distillation tower and the multi effect distillation water machine tower adopt outer coil heat exchange:
Indirect heat exchange isolates the heat source medium from pure water, preventing metal ions and grease from infiltrating the injection water; The entire process is sterile and sealed, and the produced water quality meets the standards of pharmacopoeia injection water.
3. Aseptic liquid and buffer preparation tower
Infusion, freeze-dried powder injection buffer salt, liquid medicine mixing: outer coil tube for cold and hot temperature regulation dissolves excipients, temperature control mixing, zero dead angle on the inner wall, CIP fully automatic cleaning with no risk of cross contamination.
4、 Production of medicinal excipients and health products
1. Synthesis of medicinal polymer excipients
Hydroxypropyl methylcellulose (HPMC), magnesium stearate, coating resin, disintegrant, etc. are synthesized by reaction, and the outer tube is used for correct temperature control polymerization to ensure uniform molecular weight of excipients;
2. Plant extracts from health products
Extract and concentrate tonics such as ginseng, lingzhi, wolfberry, cordyceps, etc., and preserve active polysaccharides and saponins at low temperatures;
3. Syrup and paste boiling tower
Traditional Chinese medicine paste formula and oral syrup are vacuum boiled, and the outer tube is evenly heated to prevent the bottom from sticking. The high viscosity syrup flows smoothly without any local burnt or unpleasant odor.
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